Magnesium Glycinate

Magnesium glycinate is elemental magnesium chelated to glycine. Each magnesium ion is bonded to two glycine molecules, the amino acid that carries it across your gut wall. Each Revivify serving delivers 275 mg of elemental magnesium across three capsules, the full clinical dose used in sleep and anxiety research.

Glycinate is the gentle, brain-permeable form of magnesium. Around 80 to 90% of it absorbs, versus under 4% for the magnesium oxide most drugstore bottles use. Glycine itself is also an inhibitory neurotransmitter, so the binding partner is doing calming work alongside the magnesium it carries.

Magnesium is a cofactor in more than 300 enzymatic reactions in the body. Without it, your nervous system cannot calm down, your muscles cannot release after they contract, and your cells cannot make ATP, the energy currency every system runs on.

Two mechanisms drive the calming effect. Magnesium activates GABA receptors, the brain's main inhibitory system, which is the same one alcohol borrows when it makes you drowsy. It also blocks NMDA receptors from over-firing, which is the chemistry behind racing-thought insomnia and shoulder-bracing tension.

Glycinate adds a third lever. Glycine is itself an inhibitory neurotransmitter that supports deep sleep. The form is doing more than carrying magnesium. It is reinforcing the same outcome from a second angle.

For healthy adults at the 275 mg elemental dose, magnesium glycinate has one of the cleanest safety profiles in the supplement world. The body excretes excess magnesium through the kidneys, and glycinate is gentle on digestion. No laxative effect at this dose.

Drug interactions to flag: magnesium can reduce absorption of bisphosphonates (osteoporosis drugs like Fosamax), tetracycline and quinolone antibiotics (Cipro, Levaquin), and levothyroxine. Separate doses by at least two hours. Larger amounts can also interact with diuretics and proton-pump inhibitors (Prilosec, Nexium).

Talk to your doctor first if you are pregnant or breastfeeding, under 18, on prescription medication, or have kidney disease. The kidneys clear magnesium, so if they are not working at full capacity, the math changes.

Three capsules a day, ideally 30 to 60 minutes before bed. That delivers the full 275 mg of elemental magnesium in the window where it does the most work, calming the nervous system into sleep.

Some people split the dose. One capsule with dinner and two before bed works well if you want a calmer evening as well as a deeper sleep. Glycinate does not sedate, so daytime dosing is fine if muscle recovery or daytime stress is the priority.

Most people are fine on an empty stomach. If yours is sensitive, take it with a meal. Consistency matters more than timing. Magnesium replenishes in tissue gradually over weeks, not hours.

No prescription needed. Revivify magnesium glycinate is sold as a dietary supplement. You can order directly from our website without a doctor's visit, telehealth call, or prescription. We ship straight to your door.

The evening calm tends to show up first. Within the first few days, most people notice the shoulders dropping in the evening, the wind-down getting easier, and the looping thoughts quieting before bed.

Sleep deepens over the next two to three weeks. Sleep onset gets shorter. Sleep holds steadier through the night. Mornings come back clearer. Muscle cramps and twitchy legs usually settle around week three as tissue magnesium replenishes.

Baseline anxiety and stress regulation tend to shift at month one to two. That is the part where the bracing pattern itself starts to soften and the nervous system finds neutral on its own, not just at bedtime. Our 60-day window covers the full arc.

No. Glycinate is one of the few magnesium forms that does not cause the laxative effect at clinical doses. The chelation to glycine changes how it absorbs. It crosses the gut wall as a complete molecule rather than pulling water into the intestine the way oxide does.

The famously laxative forms are magnesium oxide (the drugstore default) and magnesium citrate at higher doses. Both are poorly absorbed, and the un-absorbed magnesium is what drags water into the bowel. Glycinate does not behave that way. It is the form clinicians reach for when sleep, calm, and muscle tension are the goal and digestive disruption is not on the table.

Magnesium glycinate stacks well with most things. L-theanine, glycine (already in the formula), B6, and vitamin D all complement the calming and sleep work. NAD+ precursors, CoQ10, and adaptogens combine fine. Calcium is also fine but absorbs better when separated by about two hours.

The interactions to watch are with prescription drugs. Magnesium reduces absorption of bisphosphonates, tetracycline and quinolone antibiotics, and levothyroxine. Space those doses by at least two hours. Larger amounts can interact with diuretics and proton-pump inhibitors.

If you take any prescription medication, talk to your doctor before adding magnesium. When in doubt, ask your pharmacist about specific timing.

Most magnesium sold cheap is oxide or citrate. Under 4% bioavailable for oxide, around 25 to 30% for citrate. Both come with the laxative side effect that gives magnesium its bathroom reputation. The dose on the label looks impressive, but most of it never reaches your bloodstream.

Revivify is 100% glycinate. Chelated to glycine, around 80 to 90% bioavailable, brain-permeable, and gentle on digestion. We deliver 275 mg of elemental magnesium per serving, the full clinical dose used in sleep research, across three capsules.

Every batch is tested by an independent ISO 17025 lab for identity, potency, heavy metals, and microbial counts. A lot-matched Certificate of Analysis ships with every bottle.

Manufactured in the United States in a GMP-certified facility. Every production batch is tested by an independent ISO 17025 lab for heavy metals (lead, mercury, arsenic, cadmium), microbial counts, identity, and potency.

A Certificate of Analysis is matched to the lot number on every bottle we ship. If you want to verify your specific bottle, email us your lot number and we will send the lab report.

Free shipping on every order in the United States. Most orders ship within 24 hours from our warehouse. Standard delivery is 3 to 7 business days. Expedited is 2 business days.

International orders ship via standard international carriers. Delivery times and customs vary by destination, typically 7 to 14 business days for most countries. Tracking numbers are sent by email as soon as your order leaves our facility.

60-day money-back guarantee. Take it every day for 60 days. If your sleep has not deepened, the cramps have not quieted, and the evening calm has not come back, email us within 60 days of receiving your bottle and we will refund your order in full. Empty bottles accepted. You do not need to ship anything back.

No forms to fill out. No return shipping. No follow-up questions. No retention scripts. One email is the whole process.

Magnesium takes a few weeks to fully replenish in tissue, so we built the window around the timeline, not around making refunds hard to claim.

Yes, anytime. The Monthly Protocol (subscription) saves you 15% per shipment and arrives every 30 days. You can pause, change frequency, skip a shipment, or cancel from your account dashboard at any time.

No phone calls, no retention scripts, no fees. Edit, skip, or cancel up to 24 hours before your next ship date and we will honor it.